Season 2, Episode 23

Breaking Down silos and Democratizing Access to Diagnostics

This episode's guest:

Anant Madabhushi, PhD

This episode of Digital Pathology Today™ our guest is Anant Madabhushi, PhD. Case Western Reserve University.

Our guest is one of the giants in the field of digital pathology and image analysis. And if he has seen further than others, he will tell you, it is because he was able to stand on the shoulders of giants as well. His unique multidisciplinary approach has allowed him to breakdown silos and see across the often-artificial barriers and distinctions imposed by academic disciplines and patient treatment paradigms.

We're talking with Professor Anant Madabhushi, Director of the Center for Computational Imaging and Personalized Diagnostics and Professor of Biomedical Engineering, Radiology, Pathology Urology and Radiation Oncology at Case Western Reserve University.

We discuss silos in academic departments and disease states and how looking beyond these limitations can propel progress. What exactly is image analysis, what if we've been able to do with it so far and what predictive and prognostic information can we unlock from histologic features. And finally, how can an image analysis and non-tissue destructive computational and AI powered methods help to democratize access to care and lead to better outcomes for patients across the world.

More About Anant Madabhushi, PhD

Anant Madabhushi, PhD

Donnell Institute Professor, Biomedical Engineering, Case School of Engineering

Director, Center for Computational Imaging & Personalized Diagnostics

Case Western Reserve University

Anant Madabhushi, PhD, is the Donnell Institute Professor of biomedical engineering at Case Western Reserve University (CWRU) in Cleveland and director of the university’s Center for Computational Imaging and Personalized Diagnostics (CCIPD). He is also a Research Scientist at the Louis Stokes Cleveland Veterans Administration (VA) Medical Center and has affiliate appointments both at University Hospitals and Cleveland Clinic. He holds secondary appointments in the departments of Biomedical Engineering, Urology, Radiology, Pathology, Radiation Oncology, Electrical Engineering & Computer Science and Gen Med Sciences at CWRU.

Madabhushi’s team at CCIPD is developing and applying novel Artificial Intelligence and machine learning approaches for the diagnosis, prognosis and prediction of therapy response for a variety of diseases including several different types of cancers, cardiovascular disease, kidney and eye disease. The Center is located in Cleveland’s unique medical ecosystem, an extensive clinical network within which it boasts numerous successful collaborations including with the Cleveland Clinic and the Cole Eye Institute, University Hospitals, the VA Louis Stokes Medical Center, MetroHealth, and the Case Comprehensive Cancer Center at CWRU.

Madabhushi has more than 100 patents either issued or pending in the areas of medical image analysis, computer-aided diagnosis, and computer vision, more than 60 of which are issued. He was responsible for more than 10 percent of all patents awarded to Case Western Reserve University in 2017, 2018 and 2019.

The author of more than 400 peer-reviewed journal articles and conference papers, Madabhushi is a sought after lecturer who has delivered more than 345 talks around the world. His efforts as a professor and researcher have gained international attention in the field of biomedical engineering, garnering him several awards. Most notably, Madabhushi is a fellow of the American Institute of Medical and Biomedical Engineering (AIMBE), a Fellow of the Institute of Electrical and Electronics Engineers (IEEE) and a fellow of the National Academy of Inventors (NAI). In 2015, he made Crain’s Cleveland Business magazine’s “Forty under 40” list. In 2019 and 2020, Madabhushi was named to The Pathologist's Power List, a list of 100 most inspiring professionals in pathology and laboratory medicine. In 2020, he received the Diekhoff Award for Distinguished Graduate Student Mentoring at CWRU.

Madabhushi’s work on developing “smart computers for identifying lung cancer patients who will benefit from chemotherapy” was ranked as one of the top 10 medical breakthroughs of 2018 by Prevention Magazine. In 2019, Nature Magazine called him out as one of five scientists pursuing truly offbeat and innovative approaches in cancer research. His work on using AI for addressing health disparities, especially in identifying differences in appearance of prostate cancer between black and white men, received national attention in 2020.

Madabhushi has secured more than $60 million in grant funding and co-founded two companies, Vascuvis Inc. (now Elucid Bioimaging) and IbRiS Inc., which was acquired by Inspirata in 2015. He has been involved in several sponsored research and industry partnerships with medical imaging and pharmaceutical companies. In addition, more than 15 technologies developed by Madabhushi’s team have been license